thomas delauer keto Binge Eating Disorder | How to Stop Food Cravings | Sleep Deprivation & Overeating

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Binge Eating Disorder | How to Stop Food Cravings | Sleep Deprivation & Overeating - Thomas DeLauer

Study - Sleep

Published in the journal Sleep, researchers had 14 men and women spend two four-day sessions in a clinical research center.

They compared 4 nights of normal (8.5 h) vs restricted sleep (4.5 h) and examined the 24-h profiles of circulating concentrations of the endocannabinoid 2-arachidonoylglycerol (2-AG)

During each stay, participants ate identical meals at 9 AM, 2 PM, and 7 PM

Researchers found that when sleep-deprived, volunteers had higher and more persistent levels of endocannabinoid 2-AG

In well-rested volunteers, levels of 2-AG rose in the morning, peaked around midday, and declined again.

But in the sleep-deprived, levels rose 33% higher, peaked at 2pm, and remained high until 9pm.

https://www.ncbi.nlm.nih.gov/pmc/arti...

Nucleus Accumbens

Increased activity in the NAc is correlated with the presence of a sodium appetite.

Sodium depletion alters how the nervous system, including structures within the mesolimbic dopamine system, processes the taste of salt.

Sodium deficiency reduces gustatory nerve responses to salt - Neurons within the NST, which receives afferent information from the gustatory nerves, also exhibit altered firing patterns to the taste of salt during deficiency.

Expression of CB1 in the NAc is low, manipulation of CB1 signaling within the NAc triggers robust emotional/motivational alterations.

CB1-expressing neurons in the NAc, although sparse, appear to be critical for emotional and motivational responses.

https://www.ncbi.nlm.nih.gov/pubmed/2...

https://www.ncbi.nlm.nih.gov/pubmed/2...

Negative Control of Leptin

Leptin levels are negatively correlated with 2AG - as leptin rises, 2AG declines

https://www.ncbi.nlm.nih.gov/pubmed/1...

Fatty Foods

PNAS

Fatty food activates CB1 receptors in part of the upper intestine, the jejunum.

Researchers found that it was only fat - not sugar or protein-laden liquids - that activated gut CB1 receptors.

Also found that when they blocked CB1 receptors with a drug, rats lost interest in eating additional fat (but not other types of food)

https://www.pnas.org/content/108/31/1...

thomas delauer keto Binge Eating Disorder | How to Stop Food Cravings | Sleep Deprivation & Overeating
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